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Diagnostics for a Better Tomorrow
At Durin Technologies Inc., we believe that early disease detection is the key to increasing the prospects for successful treatment outcomes. Our focus lies in developing diagnostic tests for the most prevalent and devastating neurodegenerative diseases that make possible both early detection and monitoring of disease progression.
2020 Edison Patent Award Recipient
Dr. Robert G Nagele
Rowan University and inventor Dr. Robert G Nagele receives a patent award in the Medical Health Diagnostic category for “Diagnostic Biomarker Profiles for the Detection and Diagnosis of Alzheimer’s Disease” (U.S. 10,132,817). This invention provides methods, compositions and kits for a blood test for early diagnosis of Alzheimer’s disease (AD) based on detection of disease-specific autoantibodies as blood-based biomarkers. The goal is to definitively diagnose early-stage AD in patients that arrive for the first time in their doctor’s office with a cognitive or memory complaint. Currently, diagnosing early-stage AD has been difficult and often inconclusive even after using expensive neuropsychological evaluations and brain imaging. This test is based on the finding that all humans have thousands of self-reactive antibodies (called autoantibodies) in their blood that function to clear cell and tissue debris their bodies generate daily. Relevant to the patent, in the presence of disease, the amount of cell debris produced and released into the blood by the diseased organs or tissues is dramatically increased. In response, the immune system markedly increases production of the specific autoantibodies charged with clearing this disease-specific debris from the blood. This new test uses a single drop of blood to detect the increased levels of these disease-associated autoantibodies as blood-based biomarkers for early AD detection. Thus far, there are no blood-based diagnostic tests for early-stage AD. The development of an accurate, relatively noninvasive, inexpensive blood-based diagnostic test for early stages of AD will be of great benefit to patients afflicted with this disease since early treatment greatly increases the likelihood of a successful outcome. In addition, it would allow earlier enrollment into AD clinical trials seeking new treatments and would also facilitate the monitoring of disease progression in patients who are under treatment by their physicians or participating as subjects in clinical trials. Rowan University has licensed a portfolio of technologies in the neurodegenerative sector (including this patent) to a startup, Durin Technologies. Durin has managed to raise significant investment from different sources and is currently moving forward in seeking FDA approval for blood-based tests for preclinical (presymptomatic) AD, prodromal AD and mild-moderate AD using autoantibodies as biomarkers and human protein microarrays as a platform.
Early Detection of Alzheimer's Disease-Related Pathology Using a Multi-Disease Diagnostic Platform Employing Autoantibodies as Blood-Based Biomarkers. J Alzheimers Dis. 2023 Feb 21. doi: 10.3233/JAD-221091. Epub ahead of print. PMID: 36847005
Evidence that Brain-Reactive Autoantibodies Contribute to Chronic Neuronal Internalization of Exogenous Amyloid-β1-42 and Key Cell Surface Proteins During Alzheimer's Disease Pathogenesis
Journal of Alzheimer's Disease March 10, 2020
The origin and nature of the complex autoantibody profile in cerebrospinal fluid
Brain, Behavior, & Immunity - Health December 29, 2019
Detection of early-stage Alzheimer's pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients.
PLoS One November 15, 2019
Autoantibodies as diagnostic biomarkers for the detection and subtyping of Multiple Sclerosis
Journal of Neuroimmunology May 19, 2017
Detection of Alzheimer’s disease at Mild Cognitive Impairment and disease progression using autoantibodies as blood-based biomarkers
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring April 12, 2016
Serum autoantibodies as biomarkers for Parkinson’s disease: background and utility
AIMS Medical Science October 10, 2015
Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline
Brain Research September 16, 2015
Potential utility of autoantibodies as blood-based biomarkers for early detection and diagnosis of Parkinson's disease
Immunology Letters September 16, 2015
Utility of autoantibodies as biomarkers for diagnosis and staging of neurodegenerative disease
International Review of Neurobiology June 19, 2015
Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease
PLoS One April 2, 2013
Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib
Journal of Alzheimer's Disease March 29, 2013
Neuronal PAD4 expression and protein citrullination: possible role in production of autoantibodies associated with neurodegenerative disease
Journal of Autoimmunity May 2, 2012
Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera
PLoS One February 22, 2012
Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera
PLoS One August 3, 2011
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